(By authority conferred on the director of the department of community health by  
sections 16145 and 17701 of 1978 PA 368, MCL 333.16145 and 333.17701 et seq. and  
Executive Reorganization Order Numbers 1996-1, 1996-2, and 2003-1, being MCL  
330.3101, 445.2001, and 445.2011)  
R 338.3051 Definitions.  
Rule 1. (1) As used in parts 1 and 2 of the centralized prescription processing rules,  
R 338.3051 to R 338.3054:  
(a) "Centralized prescription processing center" means a pharmacy operated under  
the direction of a pharmacist that processes information related to the practice of  
pharmacy and engages in centralized prescription processing.  
(b) "Centralized prescription processing" is the term defined in section 17753(3) of the  
(c) "Code" means 1978 PA 368, MCL 333.1101 et seq.  
(d) "Deliver" as used in this part means to issue a prescription drug, including a  
controlled substance, directly to a patient or a patient's agent by the lawful order of a  
practitioner. A centralized prescription processing center that provides a prescription  
product to another pharmacy for subsequent issuance to a patient or a patient's agent  
has not met the definition of deliver as defined in this subrule.  
(e) "Delivering pharmacist" means a pharmacist who is responsible for delivering a  
prescription directly to a patient or a patient's agent.  
(f) "Delivering pharmacy" means the pharmacy that delivers the filled or refilled  
prescription to the patient or the patient's authorized representative. The  
delivering pharmacy shall be either the originating pharmacy or the centralized  
prescription processing center.  
(g) "Originating pharmacy" means a pharmacy that initially receives a patient's or a  
prescribing practitioner's request to fill or refill a prescription.  
(2) The terms defined in the code have the same meanings when used in these rules.  
History: 2008 AACS.  
R 338.3052 Centralized prescription processing rules; prevail over other  
pharmacy rules.  
Rule 2. To the extent that any rule in parts 1 and 2 of the centralized prescription  
processing rules conflicts with other board of pharmacy rules, the provisions in parts 1  
and 2 of the centralized prescription processing rules shall prevail.  
Page 1  
History: 2008 AACS.  
R 338.3053 Centralized prescription processing; requirements.  
Rule 3. (1) In addition to complying with the requirements of section 17753 of the  
code, a pharmacy may perform centralized prescription processing services or outsource  
these services to another pharmacy. Pharmacies that perform or outsource prescription  
processing services shall meet all of the following requirements:  
(a) Be licensed by the Michigan board of pharmacy.  
(b) Share sufficient patient and drug information to minimize the possibility of an  
adverse drug event.  
(c) Maintain prescription information or an equivalent record, as prescribed in  
section 17752(1) of the code, and the records required in R 338.3054 of this part, for 5  
years. A centralized prescription processing center and an originating pharmacy shall  
ensure that the information is readily retrievable within 48 hours after the board's agent  
makes a request for the information. If the records are maintained in a digital format, a  
printed copy shall be made available immediately to the board's agent upon request.  
(2) A pharmacy engaging in centralized prescription processing shall be responsible  
for each function of the prescription's processing performed by that pharmacy.  
(3) A delivering pharmacist shall be responsible for complying with R 338.490(4)  
regarding patient counseling.  
(4) The prescription label for a prescription that was filled by a centralized  
prescription processing center shall identify each pharmacy that was involved in  
preparing and delivering a prescription. A centralized prescription processing center  
may be identified on a prescription label by use of a unique identifier that is recognized  
by the delivering pharmacist. As used in this subrule, "unique identifier" means a unique  
combination of letters, numbers, or symbols that allows the delivering pharmacy to  
identify the specific centralized prescription processing center involved in the  
processing of the prescription. A centralized prescription processing center shall create  
and maintain a unique identifier and shall communicate the unique identifier to all  
pharmacies that use its services.  
(5) A prescription that was not delivered to a patient may be transferred back to the  
pharmacy that filled the prescription, provided that the transfer records are maintained. A  
centralized prescription processing center and an originating pharmacy shall establish  
procedures for the disposition of prescription medication that was not delivered to  
patients. This medication may be returned to stock and may be re-delivered without  
constituting a violation of R 338.472(1).  
(6) A pharmacy that performs or contracts for centralized prescription services shall  
comply with the procedures described in its policies and procedures manual, as  
provided in section 17753(2) of the code.  
History: 2008 AACS.  
R 338.3054 Records maintenance; requirements for centralized prescription  
processing pharmacies.  
Page 2  
Rule 4. (1) An originating pharmacy shall maintain records that indicate all of the  
(a) The date the request for centralized prescription processing services was  
transmitted to a centralized prescription processing center.  
(b) The method of transmittal.  
(c) The identification of the pharmacist responsible for the transmission.  
(d) The name and address of the centralized prescription processing center to which  
the request for centralized prescription processing services was transmitted.  
(e) The date the delivering pharmacy received the filled prescription from the  
centralized prescription processing center.  
(f) The name of the pharmacy employee who accepted the delivery of a filled  
prescription from a centralized prescription processing center.  
(g) The identification of the pharmacist who was responsible for delivering the  
prescription to the patient or the patient's agent.  
(2) A centralized prescription processing center that receives the transmitted  
prescription shall maintain records that indicate all of the following, as applicable to  
its function:  
(a) The date the request for centralized prescription processing services was received  
from the originating pharmacy.  
(b) The name and address of the originating pharmacy from which the request for  
centralized prescription processing services was received.  
(c) The date the prescription was processed, verified, or filled.  
(d) The identification of any pharmacist who was responsible for processing the  
prescription and shipping a filled prescription to an originating pharmacy or  
delivering a filled prescription to a patient or a patient's agent.  
(e) The date the filled prescription was shipped to the originating pharmacy or was  
shipped or delivered to the patient or the patient's agent.  
(f) If shipped, the name and address of the patient to whom the filled prescription  
was shipped.  
(g) The method of delivery, such as private, common, or contract carrier, if shipped.  
(3) If a prescription was not delivered to a patient and was transferred back to the  
pharmacy that filled the prescription, that pharmacy shall maintain the transfer  
History: 2008 AACS.  
R 338.3055 Schedule 2, 3, 4, or  
controlled substances prescriptions;  
requirements for centralized prescription processing pharmacies.  
Rule 5. (1) In addition to complying with the requirements of Part 1 of these rules, a  
pharmacy that performs or contracts for centralized prescription processing services  
shall comply with this rule when processing a prescription for a schedule 2, 3, 4, or 5  
controlled substance.  
Page 3  
(2) Prescriptions for controlled substances may be transmitted electronically,  
including by facsimile, from an originating pharmacy to a centralized prescription  
processing center.  
(3) An originating pharmacy that transmits prescription information for a controlled  
substance to a centralized prescription processing center shall comply with all of the  
(a) Ensure that the words "CENTRAL FILL" are on the face of the  
prescription and record all of the following information: the name, address, and the  
federal drug enforcement administration (dea) registration number of the centralized  
prescription processing center to which the prescription had been transmitted; the name  
of the pharmacist at the originating pharmacy who transmitted the prescription; and, the  
date of transmittal.  
(b) Ensure that all information that is required to be on a prescription pursuant to the  
provisions of 21 C.F.R. ยง1306.05 and R 338.3161 is transmitted to the centralized  
prescription processing center either on the face of the original prescription or in the  
electronic transmission of prescription information.  
(c) Indicate in the prescription information that is transmitted, the number of refills  
already dispensed and the number of refills remaining.  
(d) Maintain the original prescription for a period of 5 years from the date the  
prescription was filled.  
(4) In addition to complying with the requirements in R 338.3053 (2)(a), (b), (c), (d),  
(e), (f) and (g), a centralized prescription processing center that receives the transmitted  
prescription shall comply with both of the following:  
(a) Maintain records for 5 years.  
(b) Keep a copy of the prescription if it was sent via facsimile or an electronic record  
of all the information transmitted by the originating pharmacy, including the name,  
address, and dea registration number of the originating pharmacy that transmitted the  
History: 2008 AACS.  
R 338.3056 Reporting to the electronic system for monitoring controlled  
Rule 6. As used in this part, the pharmacy that uses its stock to fill a prescription for a  
controlled substance shall be the pharmacy responsible to report to the department or  
the department's contractor the information required in R 338.3162b for each  
prescription of a controlled substance.  
History: 2008 AACS.  
Page 4